Erratum to: CMTX1 patients’ cells present genomic instability corrected by CamKII inhibitors
نویسندگان
چکیده
Author details NORT. UMR INSERM 1062, INRA 1260, Aix Marseille Université, Campus Santé La Timone, 27 boulevard Jean Moulin, Marseille 13385 Cedex 53, France. Department of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Muenster, Germany. Department of Neurology, Aachen RWTH University Clinic, Aachen, Germany. Service de Microscopie Electronique, Faculté de Médecine de la Timone, 27 boulevard Jean Moulin, Marseille 13385 Cedex 53, France. Laboratoire d’Innovation thérapeutique, UMR7200, CNRS, Université de Strasbourg, Faculté de Pharmacie, 74, route du rhin, Illkirch Graffenstaden 67400, France.
منابع مشابه
CMTX1 patients’ cells present genomic instability corrected by CamKII inhibitors
BACKGROUND We previously described that fibroblasts from animal models of CMTX1 present genomic instability and poor connexon activity. In vivo, these transgenic mice present motor deficits. This phenotype could be significantly reverted by treatment with (CamKII) inhibitors. The objective of this study is to translate our findings to patients. METHODS We cultured fibroblasts from skin biopsi...
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Mutation in the Gjb1 gene, coding for a connexin (Cx32), is associated with an inherited peripheral neuropathic disorder (X-linked Charcot-Marie-Tooth, CMTX). Our previous work reported that transgenic animals expressing a human Gjb1 transgene present polyploidy and abnormal over-duplication of the centrosome, suggesting a role for Gjb1 in mitotic stability. In this article, we propose mechanis...
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